Quadriplegia is a severe disorder causing paralysis of the four limbs and torso. Unfortunately, it also impairs a number of aspects of normal functioning, including sleep. In people with quadriplegia, sleep disordered breathing, mainly obstructive sleep apnoea (OSA), is estimated to be 2 to 5 times higher than in able-bodied people. In order to find a suitable treatment for quadriplegic people with OSA, we need to better understand how OSA develops in those with quadriplegia. In this study we will investigate the structure and muscular control of the upper airway, which is known to contribute to OSA in able-bodied individuals. Given the inability to cure quadriplegia itself, any development which helps understand and improve other aspects of this terrible condition will be of significant importance.
Pathogenesis of Obstructive Sleep Apnoea in Quadriplegia
Sleep > Obstructive Sleep Apnoea
Quadriplegia causes body paralysis and compromises daily functioning, including sleep. In quadriplegia, obstructive sleep apnoea (OSA) is estimated to be two to five times more prevalent than in able-bodied people.
We investigated upper airway anatomy and neuromuscular control in quadriplegia and able-bodied individuals. People with quadriplegia were found to have lower lung volumes with impaired upper airway function and airway sensations. The results highlight potential risk factors for OSA in quadriplegia and could enable the development of suitable treatments.
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