Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease

AuthorsPassey, S.L.
Hansen, M.J.
Bozinovski, S.
McDonald, C.F.
Holland, A.E.
Vlahos, R.
TypeJournal Article (Original Research)
JournalPharmacology & therapeutics
PubMed ID27373503
Year of Publication2016
URLhttp://www.ncbi.nlm.nih.gov/pubmed/27373503
DOIhttp://dx.doi.org/10.1016/j.pharmthera.2016.06.013
Download 1-s20-S0163725816301036-main_.pdf (907.6 KB)
AbstractChronic obstructive pulmonary disease (COPD) is a progressive lung disease that constitutes a major global health burden. A significant proportion of patients experience skeletal muscle wasting and loss of strength as a comorbidity of their COPD, a condition that severely impacts on their quality of life and survival. At present, the lung pathology is considered to be largely irreversible; however, the inherent adaptability of muscle tissue offers therapeutic opportunities to tackle muscle wasting and potentially reverse or delay the progression of this aspect of the disease, to improve patients' quality of life. Muscle wasting in COPD is complex, with contributions from a number of factors including inflammatory cytokines, oxidative stress, growth and anabolic hormones, nutritional status, and physical activity. In this review, we discuss current and emerging therapeutic approaches to treat muscle wasting in COPD, including a number of pharmacological therapies that are in development for muscle atrophy in other pathological states that could be of relevance for treating muscle wasting in COPD patients.

http://www.ibas.org.au/what-we-do/publications/3872823


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