Cognition and Alzheimer's risk in OSA

Obstructive Sleep Apnoea (OSA) is a highly prevalent chronic illness, characterised by repetitive collapse of the airway during sleep, causing falls in blood oxygen levels and sleep disruption. OSA is associated with cognitive deficits, especially memory impairments. Another common condition, dementia, is in the top 4 causes of burden of disease of high-income nations. It affects over 340,000 Australians. OSA is common in patients with dementia, with estimates of 38-45% of dementia patients having OSA. The risk of Alzheimer's Disease (AD) and vascular dementia has been shown to increase in patients with OSA. However, a direct causal link between these two conditions has not been established.
Beta-amyloid deposits are commonly found in the brains of patients with dementia, and are implicated in the development of dementia. Positron emission tomography (PET) can be used to assess levels of amyloid in the brains of patients, and these levels can be associated with cognitive function. Previous studies performed at Austin Health have found significant associations between amyloid levels and memory impairment in patients with mild cognitive impairment. To date, no studies have examined whether OSA is associated with higher levels of beta amyloid deposits or AD-type neural changes, or how these changes relate to cognitive performance.
This study will use PET scanning techniques to examine the levels of amyloid in the brains of patients with OSA, and compare these to brain scans of healthy controls from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. This study will also conduct cognitive assessments in the OSA patients and examine associations between cognitive performance and amyloid levels.
Identifying potential biomarkers of amyloid burden in OSA could have important implications for early detection and risk assessment. Early identification of the risk of developing dementia in patients with OSA is important as it allows the possibility of a simple intervention that targets the sleep disorder that may be contributing towards the development of neural and cognitive impairment, before it progresses to dementia.


Full Name

Amyloid deposition and cognitive function in Obstructive Sleep Apnoea

Primary Investigator

Melinda Jackson

Stream

Sleep > Obstructive Sleep Apnoea

Donate

Consider making a donation to help us learn more about obstructive sleep apnoea and other disorders. You can make an important contribution to the work of our research teams through a financial donation.



ARIELARIEL

Interstitial lung disease (ILD) is a chronic lung condition that causes stiff lungs and restricts sufferers from taking a deep breath. Exercise in a gym, or swimming, walking or riding a bike, can help...

Shift work and breastfeeding projectSHIFT WORK AND BREASTFEEDING PROJECT

Researchers at Austin Health are looking for volunteers to participate in a study exploring the impact shift work has on breast milk composition. Participants will be compensated with a $100 gift voucher.

Notch monitoring in sleepNOTCH MONITORING IN SLEEP

Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...

A/Prof Mark Howard Awarded Major Competitive MRFF GrantA/PROF MARK HOWARD AWARDED MAJOR COMPETITIVE MRFF GRANT

IBAS leads project to revolutionize Home Ventilation with $1.2 million grant for Assoc. Prof Mark Howard's research titled "Synchronise non-invasive ventilation at home".

Prof Anne Holland receives prestigious Research AwardPROF ANNE HOLLAND RECEIVES PRESTIGIOUS RESEARCH AWARD

Prof Anne Holland receives prestigious award for Excellent in Research Engagement and Impact from Monash University.

World Sleep Day on 17th March 2023WORLD SLEEP DAY ON 17TH MARCH 2023

The benefits of quality sleep and to acknowledge the issue of sleep problems and their medical, educational, and social aspects as well as the prevention and management of sleep disorders, is promoted on World Sleep Day on the 17th March 2023.

A/Prof Mark Howard is listed in 'the Australian'A/PROF MARK HOWARD IS LISTED IN 'THE AUSTRALIAN'

The Australian's Research magazine names the top researcher and top research institution in each field of research, based on the number of citations for papers published in the top 20 journals in each field over the past five years.

Institute for Breathing and Sleep

Level 5, Harold Stokes Building, Austin Health
145 Studley Road
Heidelberg, Victoria, 3084

(03) 9496 5390

Email Us

Donate