| Authors | Dang, Christa Harrington, Karra D Lim, Yen Ying Ames, David Hassenstab, Jason Laws, Simon M Yassi, Nawaf Hickey, Martha Rainey-Smith, Stephanie R Robertson, Joanne |
|---|---|
| Type | Journal Article (Original Research) |
| Journal | Archives of Clinical Neuropsychology |
| PubMed ID | 30272115 |
| Year of Publication | 2018 |
| URL | http://ahro.austin.org.au/austinjspui/handle/1/19689 |
| DOI | https://doi.org/10.1093/arclin/acy078 |
| Abstract | To prospectively examine 8-year risk of clinical disease progression to mild cognitive impairment (MCI)/dementia in older adults ≥60 with superior episodic memory (SuperAgers) compared to those cognitively normal for their age (CNFA). Additionally, to determine the extent to which SuperAgers were resilient to the negative effects of elevated amyloid-beta (Aβ+) on cognition. SuperAgers displayed resilience against clinical progression to MCI/dementia compared to CNFA despite equivalent risk for Alzheimer's disease (AD); however, SuperAgers had no greater protection from Aβ+ than CNFA. The deleterious effects of Aβ on cognition persist regardless of baseline cognitive ability. Thus, superior cognitive performance does not reflect resistance against the neuropathological processes associated with AD, and the observed resilience for SuperAgers may instead reflect neuropsychological criteria for cognitive impairment. |
http://www.ibas.org.au/what-we-do/publications/3872999
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