| Authors | Bourgeat, Pierrick Doré, Vincent Fripp, Jurgen Ames, David Masters, Colin L Salvado, Olivier Villemagne, Victor L Rowe, Christopher C |
|---|---|
| Type | Journal Article (Original Research) |
| Journal | NeuroImage |
| PubMed ID | 30130643 |
| Year of Publication | 2018 |
| URL | http://ahro.austin.org.au/austinjspui/handle/1/18211 |
| DOI | https://doi.org/10.1016/j.neuroimage.2018.08.044 |
| Abstract | The centiloid scale was recently proposed to provide a standard framework for the quantification of β-amyloid PET images, so that amyloid burden can be expressed on a standard scale. While the framework prescribes SPM8 as the standard analysis method for PET quantification, non-standard methods can be calibrated to produce centiloid values. We have previously developed a PET-only quantification: CapAIBL. In this study, we show how CapAIBL can be calibrated to the centiloid scale. Calibration images for 11C-PiB, 18F-NAV4694, 18F-Florbetaben, 18F-Flutemetamol and 18F- Florbetapir were analysed using the standard method and CapAIBL. Using these images, both methods were calibrated to the centiloid scale. Centiloid values computed using CapAIBL were compared to those computed using standard method. For each tracer, a separate validation was performed using an independent dataset from the AIBL study. Using the calibration images, there was a very strong agreement, and very little bias between the centiloid values computed using CapAIBL and those computed using the standard method with R2 > 0.97 across all tracers. Using images from AIBL, the agreement was also high with R2 > 0.96 across all tracers. In this dataset, there was a small underestimation of the centiloid values computed using CapAIBL of less than 0.8% in PiB, and a small over-estimation of 1.3% in Florbetapir, and 0.8% in Flutemetamol. There was a larger overestimation of 8% in NAV images, and 14% underestimation in Florbetaben images. However, some of these differences could be explained by the use of different scanners between the calibration scans and the ones used in AIBL. The PET-only quantification method, CapAIBL, can produce reliable centiloid values. The bias observed in the AIBL dataset for 18F-NAV4694 and 18F-Florbetaben may indicate that using different scanners or reconstruction methods might require scanner-specific adjustments. |
http://www.ibas.org.au/what-we-do/publications/3872992
Interstitial lung disease (ILD) is a chronic lung condition that causes stiff lungs and restricts sufferers from taking a deep breath. Exercise in a gym, such as walking or riding a bike, can help make...
Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...
DO YOU HAVE SPINAL CORD INJURY? TIRED? GET TREATED!
Melbourne researchers have found that 80 percent of people with quadriplegic spinal injuries have sleep apnoea. It's having a big effect on their lives but they don't know they have it, and they don't know it can be treated.
WORLD 1ST HEAVY VEHICLE DRIVER FATIGUE STUDY RELEASED
The National Transport Commission (NTC) and the Cooperative Research Centre for Alertness, Safety and Productivity (Alertness CRC) have released the results of what is hailed as a world-first study into heavy vehicle driver fatigue.
AAMRI ELECTION STATEMENT RELEASED ON 25TH MARCH 2019
AAMRI released its election statement calling on politicians to commit to three main priorities: ensuring the MRFF reaches $20 billion by 2020-21, provide continued strong support for the NHMRC, and develop sustainable and rewarding career pathways.
PORTRAIT UNVEILED AT CANBERRA'S PARLIAMENT HOUSE
IBAS Director Anna Burke had barely got into the swing of her speech at the unveiling of her portrait at Canberra's Parliament House when the ringing of bells caused half her audience to hurry away.
© 2020 Institute for Breathing and Sleep. All Rights Reserved. ABN 39 093 685 879
Powered by Helmut Design | Manage
