Evidence against a subcortical gate preventing conscious detection of respiratory load stimuli

AuthorsRuehland, W.R.
Rochford, P.D.
Trinder, J.
Spong, J.
O'Donoghue, F.J.
TypeJournal Article (Original Research)
JournalRespiratory Physiology & Neurobiology
PubMed ID30130628
Year of Publication2018
URLhttps://www.ncbi.nlm.nih.gov/pubmed/30130628
DOI/10.1016/j.resp.2018.08.005
AbstractRespiratory related evoked potentials (RREP) were used to examine respiratory stimulus gating. RREPs produced by consciously detected vs. undetected loads, near the detection threshold, were compared. Participants (n = 17) were instrumented with EEG and a nasal mask connected to a loading manifold, which presented a range of mid-inspiratory resistive loads, plus a control, in a random block design. Participants were cued prior to the stimulus and signalled detection by a button press. There were statistically significant differences in peak-to-peak amplitude of the P1 RREP peak for detected (mean +/- SD; 3.86 +/- 1.45 muV; P = 0.020) and undetected loads (3.67 +/- 1.27 muV; P = 0.002) vs. control (2.36 +/- 0.81 muV), although baseline-to-peak differences were not significantly different. In contrast peak-to-peak P3 amplitude was significantly greater for detected (5.91 +/- 1.54 muV; P < 0.001) but not undetected loads (3.33 +/- 0.98 muV; P = 0.189) vs. control (3.69 +/- 1.46 muV), with the same pattern observed for baseline-to-peak measurements. The P1 peak, thought to reflect arrival of somatosensory information, appeared to be present in response to both detected and undetected loads, but the later P3 peak, was present for detected loads only. This suggests that for sub-threshold loads sensory information may reach the cortex, arguing against a sub-cortical gating process.

http://www.ibas.org.au/what-we-do/publications/3872991


< More publications



ARIELARIEL

Interstitial lung disease (ILD) is a chronic lung condition that causes stiff lungs and restricts sufferers from taking a deep breath. Exercise in a gym, such as walking or riding a bike, can help make...

Notch monitoring in sleepNOTCH MONITORING IN SLEEP

Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...

Good sleep more essential than ever during COVID-19GOOD SLEEP MORE ESSENTIAL THAN EVER DURING COVID-19

This Sleep Awareness Week, Austin Health's sleep experts remind us all that sleep is integral to good health, particularly at times when we're under stress.

Professor David Berlowitz receives over 7 million in grantsPROFESSOR DAVID BERLOWITZ RECEIVES OVER 7 MILLION IN GRANTS

University of Melbourne Chair of Physiotherapy at Austin Health, Professor David Berlowitz has had quite a memorable week.

Finally, after much demand, IBAS is now on Twitter!FINALLY, AFTER MUCH DEMAND, IBAS IS NOW ON TWITTER!

Many have asked, when will IBAS be on Twitter. We are happy to announce that IBAS is finally there!

Do you have Spinal cord injury? Tired?  Get treated!DO YOU HAVE SPINAL CORD INJURY? TIRED? GET TREATED!

Melbourne researchers have found that 80 percent of people with quadriplegic spinal injuries have sleep apnoea. It's having a big effect on their lives but they don't know they have it, and they don't know it can be treated.

Institute for Breathing and Sleep

Level 5, Harold Stokes Building, Austin Hospital
145 Studley Road
Heidelberg, Victoria, 3084

(03) 9496 5390

Email Us

Donate