Elevated serum interleukin-5 levels in severe chronic obstructive pulmonary disease

AuthorsPerret, J.
McDonald, C.
Apostolopoulos, V.
TypeJournal Article (Original Research)
JournalActa Biochim Biophys Sin (Shanghai)
Year of Publication2017
URLhttps://academic.oup.com/abbs/article-abstract/3111213/Elevated-serum-interleukin-5-levels-in-severe
DOIhttps://doi.org/10.1093/abbs/gmx030
AbstractChronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder which is now ranked third as a leading cause of death [1]. Fixed airflow obstruction that is measured by spirometry following inhaled bronchodilator is essential to its diagnosis, and in its advanced stages, systemic manifestations such as inflammation and cachexia are also characteristic. In the lung, pathological features include increased number of airway neutrophils, a cytotoxic (Tc) predominant lymphocytic response associated with lymphoid follicles containing B and T cells, and increased proinflammatory cytokines including interleukin (IL)-6 and IL-8. Lung fibrosis and parenchymal destruction, also known as emphysema, can also be the feature in addition to obstruction of small airways. Some evidence...

http://www.ibas.org.au/what-we-do/publications/3872920


< More publications



SHiQ - COSAQSHIQ - COSAQ

Each year in Australia 260 people sustain a SCI, with over half losing full function in their arms and legs (quadriplegia). In addition to the primary disability, there is a very high rate of Obstructive...

Notch monitoring in sleepNOTCH MONITORING IN SLEEP

Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...

NTC releases 'world first' heavy vehicle driver fatigue studyNTC RELEASES 'WORLD FIRST' HEAVY VEHICLE DRIVER FATIGUE STUDY

The National Transport Commission (NTC) and the Cooperative Research Centre for Alertness, Safety and Productivity (Alertness CRC) have released the results of what is hailed as a world-first study into heavy vehicle driver fatigue.

AAMRI Election Statement released on 25th March 2019AAMRI ELECTION STATEMENT RELEASED ON 25TH MARCH 2019

AAMRI released its election statement calling on politicians to commit to three main priorities: ensuring the MRFF reaches $20 billion by 2020-21, provide continued strong support for the NHMRC, and develop sustainable and rewarding career pathways.

IBAS Director Anna Burke unveils her portrait at Canberra's Parliament HouseIBAS DIRECTOR ANNA BURKE UNVEILS HER PORTRAIT AT CANBERRA'S PARLIAMENT HOUSE

Anna Burke had barely got into the swing of her speech at the unveiling of her portrait at Canberra's Parliament House when the ringing of bells caused half her audience to hurry away

National study offers hope for breathlessnessNATIONAL STUDY OFFERS HOPE FOR BREATHLESSNESS

A national medication study is aiming to help thousands of Australians who struggle every day with shortness of breath

Institute for Breathing and Sleep

Level 5, Harold Stokes Building, Austin Hospital
145 Studley Road
Heidelberg, Victoria, 3084

(03) 9496 5390

Email Us

Donate