Amyloid-Β, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men

AuthorsHolmes, E.
Esterlis, I.
Mazure, CM.
Lim, Yen Ying
Ames, D.
Rainey-Smith, S.
Martins, RN.
Salvado, O.
Dore, V.
Villemagne, VL.
Rowe, CC.
Laws, SM.
Masters, CL.
Maruff, P.
Pietrzak, Rh.
TypeResearch Report
JournalThe American Journal of Geriatric Psychiatry
Year of Publication2016
AbstractAbstractObjectives To examine how amyloid-β (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal (CN) older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle (AIBL) study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results In the full sample, Aβ+ and APOE ε4 carriage were associated with greater severity of anxiety symptoms (d=0.55); and APOE ε4 carriage with greater severity of depressive (d=0.26) and anxiety (d=0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d=0.83); and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d=0.29). Conclusions Sex moderated the relationship between Aβ and APOE genotype, and BDNF genotype in the risk for anxiety and depressive symptoms in CN older adults.

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