Associations of neighborhood environment with brain imaging outcomes in the AIBL cohort

AuthorsCerin, E.
Rainey-Smith, SR.
Ames, D.
Lautenschlager, NT.
Macaulay, SL.
Fowler, C.
Robertson, JS.
Rowe, CC.
Maruff, P.
Martins, RN.
Masters, CL.
Ellis, KA.
TypeJournal Article (Original Research)
JournalAlzheimer's & Dementia : the Journal of the Alzheimer's Association
PubMed ID27546307
Year of Publication2016
URLhttp://www.ncbi.nlm.nih.gov/pubmed/27546307
DOIhttp://dx.doi.org/10.1016/j.jalz.2016.06.2364
AbstractINTRODUCTION: "Walkable" neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. METHODS: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with Apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid beta burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE epsilon4 status, and the extent to which associations were explained by physical activity. RESULTS: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE epsilon4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. DISCUSSION: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE epsilon4 carriers) minimally attributable to physical activity.

http://www.ibas.org.au/what-we-do/publications/3872850


< More publications



ARIELARIEL

Interstitial lung disease (ILD) is a chronic lung condition that causes stiff lungs and restricts sufferers from taking a deep breath. Exercise in a gym, such as walking or riding a bike, can help make...

Notch monitoring in sleepNOTCH MONITORING IN SLEEP

Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...

SHiQ - COSAQSHIQ - COSAQ

Each year in Australia 260 people sustain a SCI, with over half losing full function in their arms and legs (quadriplegia). In addition to the primary disability, there is a very high rate of Obstructive...

Do you have Spinal cord injury? Tired?  Get treated!DO YOU HAVE SPINAL CORD INJURY? TIRED? GET TREATED!

Melbourne researchers have found that 80 percent of people with quadriplegic spinal injuries have sleep apnoea. It's having a big effect on their lives but they don't know they have it, and they don't know it can be treated.

World 1st heavy vehicle driver fatigue study releasedWORLD 1ST HEAVY VEHICLE DRIVER FATIGUE STUDY RELEASED

The National Transport Commission (NTC) and the Cooperative Research Centre for Alertness, Safety and Productivity (Alertness CRC) have released the results of what is hailed as a world-first study into heavy vehicle driver fatigue.

AAMRI Election Statement released on 25th March 2019AAMRI ELECTION STATEMENT RELEASED ON 25TH MARCH 2019

AAMRI released its election statement calling on politicians to commit to three main priorities: ensuring the MRFF reaches $20 billion by 2020-21, provide continued strong support for the NHMRC, and develop sustainable and rewarding career pathways.

Portrait unveiled at Canberra's Parliament HousePORTRAIT UNVEILED AT CANBERRA'S PARLIAMENT HOUSE

IBAS Director Anna Burke had barely got into the swing of her speech at the unveiling of her portrait at Canberra's Parliament House when the ringing of bells caused half her audience to hurry away.

Institute for Breathing and Sleep

Level 5, Harold Stokes Building, Austin Hospital
145 Studley Road
Heidelberg, Victoria, 3084

(03) 9496 5390

Email Us

Donate