Airways resistance and specific conductance for the diagnosis of obstructive airways diseases.

AuthorsTopalovic, M.
Derom, E.
Osadnik, C. R.
Troosters, T.
Decramer, M.
Janssens, W.
TypeJournal Article (Original Research)
JournalRespiratory Research
PubMed ID26194099
Year of Publication2015
URLhttp://www.ncbi.nlm.nih.gov/pubmed/26194099
Download Topalovic-2015-Airways_resistance_and_specific.pdf (2.2 MB)
AbstractBACKGROUND: Airway resistance (RAW) and specific airway conductance (sGAW) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of RAW and sGAW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD. METHODS: 976 subjects admitted for the first time to a pulmonary practice in Belgium were included. Clinical diagnoses were based on complete pulmonary function tests and supported by investigations of physicians' discretion. 651 subjects had a final diagnosis of obstructive diseases, 168 had another respiratory disease and 157 subjects had no respiratory disease (healthy controls). RESULTS: RAW and sGAW were significantly different (p < 0.0001) between obstructive and other groups. Abnormal RAW and sGAW were found in 39 % and 18 % of the population, respectively, in which 81 % and 90 % had diagnosed airway obstruction. Multiple regression revealed sGAW to be a significant and independent predictor of an obstructive disorder. To differentiate asthma from COPD, RAW was found to be more relevant and statistically significant. In asthma patients with normal FEV1/FVC ratio, both RAW and sGAW were more specific than sensitive diagnostic tests in differentiating asthma from healthy subjects. CONCLUSIONS: RAW and sGAW are significant factors that contribute to the diagnosis and differentiation of obstructive airways diseases.

http://www.ibas.org.au/what-we-do/publications/3872811


< More publications



ARIELARIEL

Interstitial lung disease (ILD) is a chronic lung condition that causes stiff lungs and restricts sufferers from taking a deep breath. Exercise in a gym, such as walking or riding a bike, can help make...

Notch monitoring in sleepNOTCH MONITORING IN SLEEP

Sleep apnea is a condition where breathing is abnormal during sleep. There are two main forms of sleep apnea: obstructive and central. For obstructive sleep apnea, breathing is reduced because the airway...

Good sleep more essential than ever during COVID-19GOOD SLEEP MORE ESSENTIAL THAN EVER DURING COVID-19

This Sleep Awareness Week, Austin Health's sleep experts remind us all that sleep is integral to good health, particularly at times when we're under stress.

Professor David Berlowitz receives over 7 million in grantsPROFESSOR DAVID BERLOWITZ RECEIVES OVER 7 MILLION IN GRANTS

University of Melbourne Chair of Physiotherapy at Austin Health, Professor David Berlowitz has had quite a memorable week.

Finally, after much demand, IBAS is now on Twitter!FINALLY, AFTER MUCH DEMAND, IBAS IS NOW ON TWITTER!

Many have asked, when will IBAS be on Twitter. We are happy to announce that IBAS is finally there!

Do you have Spinal cord injury? Tired?  Get treated!DO YOU HAVE SPINAL CORD INJURY? TIRED? GET TREATED!

Melbourne researchers have found that 80 percent of people with quadriplegic spinal injuries have sleep apnoea. It's having a big effect on their lives but they don't know they have it, and they don't know it can be treated.

Institute for Breathing and Sleep

Level 5, Harold Stokes Building, Austin Hospital
145 Studley Road
Heidelberg, Victoria, 3084

(03) 9496 5390

Email Us

Donate